Document Detail


Temporal control of neural crest lineage generation by Wnt/β-catenin signaling.
MedLine Citation:
PMID:  22573620     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wnt/β-catenin signaling controls multiple steps of neural crest development, ranging from neural crest induction, lineage decisions, to differentiation. In mice, conditional β-catenin inactivation in premigratory neural crest cells abolishes both sensory neuron and melanocyte formation. Intriguingly, the generation of melanocytes is also prevented by activation of β-catenin in the premigratory neural crest, which promotes sensory neurogenesis at the expense of other neural crest derivatives. This raises the question of how Wnt/β-catenin signaling regulates the formation of distinct lineages from the neural crest. Using various Cre lines to conditionally activate β-catenin in neural crest cells at different developmental stages, we show that neural crest cell fate decisions in vivo are subject to temporal control by Wnt/β-catenin. Unlike in premigratory neural crest, β-catenin activation in migratory neural crest cells promotes the formation of ectopic melanoblasts, while the production of most other lineages is suppressed. Ectopic melanoblasts emerge at sites of neural crest target structures and in many tissues usually devoid of neural crest-derived cells. β-catenin activation at later stages in glial progenitors or in melanoblasts does not lead to surplus melanoblasts, indicating a narrow time window of Wnt/β-catenin responsiveness during neural crest cell migration. Thus, neural crest cells appear to be multipotent in vivo both before and after emigration from the neural tube but adapt their response to extracellular signals in a temporally controlled manner.
Authors:
Lisette Hari; Iris Miescher; Olga Shakhova; Ueli Suter; Lynda Chin; Makoto Taketo; William D Richardson; Nicoletta Kessaris; Lukas Sommer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-09
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  139     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-23     Completed Date:  2012-08-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2107-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Attachment Sites, Microbiological
Biological Markers / metabolism
Body Patterning
Cell Lineage*
Cell Movement
Embryo, Mammalian / cytology,  metabolism
Ganglia, Sympathetic / cytology,  metabolism
Immunohistochemistry
Integrases / metabolism
Melanocytes / cytology,  metabolism
Mice
Microphthalmia-Associated Transcription Factor / metabolism
Microtubule-Associated Proteins / metabolism
Neural Crest / cytology*,  metabolism
Neurons / cytology,  metabolism
Neuropeptides / metabolism
SOXE Transcription Factors / metabolism
Stem Cells / cytology,  metabolism
Time Factors
Wnt Signaling Pathway*
beta Catenin / metabolism
Grant Support
ID/Acronym/Agency:
G0501173//Medical Research Council; G0800575//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Microphthalmia-Associated Transcription Factor; 0/Microtubule-Associated Proteins; 0/Mitf protein, mouse; 0/Neuropeptides; 0/SOXE Transcription Factors; 0/Sox10 protein, mouse; 0/beta Catenin; 0/doublecortin protein; EC 2.7.7.-/Cre recombinase; EC 2.7.7.-/Integrases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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