Document Detail

Temporal and constitutive expression of homeobox-2 gene (Hu-2), human heat shock gene (hsp-70), and oncogenes C-sis and N-myc in early human trophoblast.
MedLine Citation:
PMID:  2461079     Owner:  NLM     Status:  MEDLINE    
Recent studies of the genetic basis of animal development indicate that homeobox genes, protooncogenes, and some heat shock genes may play a role in early embryogenesis. To investigate the possibility that these genes function in early human embryonic development, we monitored the expression of a human homeobox gene (Hu-2), two human protooncogenes (C-sis and N-myc), and a human heat shock gene (hsp-70) in human trophoblasts at 7 to 13 weeks gestational age. All these genes were found to be expressed in the tissues analyzed. The hsp-70 gene was expressed at nearly constant levels throughout the development period surveyed, whereas N-myc, C-sis, and Hu-2 showed a coordinated pattern of regulated expression. These results are consistent with a functional role of these genes in the early course of human development.
B C Su; D Strand; P G McDonough; J F McDonald
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  159     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1195-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912.
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MeSH Terms
Blotting, Northern
Gene Expression Regulation*
Genes, Homeobox*
Gestational Age
Heat-Shock Proteins / genetics*
Nucleic Acid Hybridization
Sequence Homology, Nucleic Acid
Transcription, Genetic
Trophoblasts / physiology*
Reg. No./Substance:
0/Heat-Shock Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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