Document Detail

Temporal characteristics of capsaicin sensitization and desensitization on the tongue.
MedLine Citation:
PMID:  1648242     Owner:  NLM     Status:  MEDLINE    
Previous work has demonstrated that repeated applications of capsaicin can sensitize the tongue to subsequent exposures to capsaicin. However, if stimulation is interrupted for a period of minutes, the contrasting phenomenon of desensitization occurs. The purpose of the present study was to investigate the effect of interstimulus interval (ISI) on the development of both sensitization and desensitization to sequential capsaicin stimuli. It was determined in the first experiment that the rate of sensitization varied inversely with ISI for intervals briefer than 3.5 min; when ISI was lengthened to 5.5 min, sensitization was replaced by a trend toward desensitization. A second experiment established that increasing ISI from 9.5 min to 14.5 min tended to reduce rather than to enhance desensitization. It was therefore concluded that the sensitization process can be optimized by decreasing the time between successive stimuli (ISIs less than 3.5 min), whereas the trend toward desensitization appears to be optimal when stimuli are separated by at least 5.5 min but by less than 14.5 min.
B G Green
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  49     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-5     Citation Subset:  IM    
Monell Chemical Senses Center, Philadelphia, PA 19104-3308.
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MeSH Terms
Capsaicin / pharmacology*
Dose-Response Relationship, Drug
Synaptic Transmission / drug effects*
Taste Buds / drug effects*
Taste Threshold / drug effects*
Time Factors
Tongue / innervation*
Trigeminal Nerve / drug effects
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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