Document Detail

Temporal bone pneumatization and its relationship to paranasal sinus development in cystic fibrosis.
MedLine Citation:
PMID:  20502767     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is significant debate on the influence of inflammatory mucosal disease on paranasal sinus pneumatization (PSP) and temporal bone pneumatization (TBP) in cystic fibrosis patients (CF). It is often assumed that mucosal disease of the paranasal sinuses will negatively influence development and pneumotization of the paranasal sinuses and temporal bone system. METHODS: A case-control study of TBP and PSP in CF, chronic rhinosinusitis (CRS) and healthy control patients from a tertiary rhinology clinic. TBP and PSP were assessed by computed tomography (CT) using a previously validated scale. Genotype data for patients with CF was determined. RESULTS: In total, 186 temporal bones and paranasal sinuses from 93 adult patients were assessed through evaluation of CT scans. Tha patients had a mean age of 43.4 +/- 14.9 yrs. The interobserver correlation for TB scoring was 0.86. TBP did not differ between CF, CRS and controls (chi(2) = 6.93, p = 0.38). PSP was less in the CF group (chi(2) = 34.2, p < 0.001) than the CRS and control groups. CRS and controls did not differ in PSP. 51.6% of CF patients were homozygous for DeltaF508 and 16.1% were heterozygous. The DeltaF508 status correlated with poorer SP (chi(2) = 34.2, p < 0.001), but greater TBP (chi(2) = 14.9, p = 0.002) CONCLUSIONS: PSP is impaired in CF and DeltaF508 homozygosity is related to poor PSP. TBP is well preserved in the CF population and DeltaF508 homozygosity correlates with greater TBP, with the underlying mechanisms being unclear. Genotype might play a role in skull base pneumatization.
Clarice M Seifert; Richard J Harvey; Joe W Mathews; Ted A Meyer; Chadwick Ahn; Brad A Woodworth; Rodney J Schlosser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rhinology     Volume:  48     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Cystic Fibrosis / genetics,  pathology*
Paranasal Sinuses / pathology*,  radiography
Retrospective Studies
Rhinitis / pathology*,  radiography
Sinusitis / pathology*,  radiography
Temporal Bone / pathology*,  radiography
Tomography, X-Ray Computed

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