Document Detail

Temporal bone and lateral skull base malignancy: experience and results with 81 patients.
MedLine Citation:
PMID:  9827809     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to examine predictive factors and treatment outcome and to devise a staging method for malignant lateral skull base disease. STUDY DESIGN: The study design was a retrospective review of all lateral skull base surgery cases. SETTING: The study was conducted at a tertiary referral center. PATIENTS: Of 317 lateral skull base lesions, 81 patients were found to have malignant disease. Three groups were identified, and the data were analyzed according to the following: epithelial malignancies, 30 patients; malignancies of salivary gland origin, 23 patients; and malignancies of mesenchymal origin, 28 patients. The mean age was 48.5 years with a range of 5-83 years. There were 42 males and 39 females. Our mean follow-up time was 54 months with a range of 1-180 months. Forty-three patients were alive without evidence of recurrent disease, 6 were living with disease, 25 were dead of disease, 3 died of other causes, and 4 were lost to follow-up. INTERVENTIONS: All patients underwent surgery with curative intent. Forty-two received adjuvant radiation, and 8 received chemotherapy. MAIN OUTCOME MEASURES: Treatment failure, survival, cranial nerve deficits, complications, and predictive factors were analyzed. RESULTS: A 58% treatment success rate was observed. Epithelial and salivary malignancy had a poorer prognosis, and pain and facial nerve dysfunction at presentation carried a worse prognosis. CONCLUSIONS: Lateral skull base malignancy is a rare entity that continues to challenge cranial base surgeons. Cranial nerve deficits and complications are frequent. The success rate of treatment is dependent on histology and disease extent.
S Manolidis; D Pappas; P Von Doersten; C G Jackson; M E Glasscock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of otology     Volume:  19     ISSN:  0192-9763     ISO Abbreviation:  Am J Otol     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909513     Medline TA:  Am J Otol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S1-15     Citation Subset:  IM    
The Bobby R. Alford Department of Otolaryngology, Baylor College of Medicine, Houston, Texas 77030, USA.
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MeSH Terms
Aged, 80 and over
Brain Ischemia / etiology
Carcinoma, Squamous Cell / pathology
Child, Preschool
Disease Progression
Follow-Up Studies
Hearing Loss, Functional / diagnosis,  etiology
Middle Aged
Neoplasm Staging
Pain / etiology
Predictive Value of Tests
Retrospective Studies
Skull Base Neoplasms / complications,  pathology*,  therapy*
Temporal Bone / pathology*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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