| Temporal associations among pulses of 13,14-dihydro-15-keto-PGF2alpha, luteal blood flow, and luteolysis in cattle. | |
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MedLine Citation:
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PMID: 17151348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Luteal blood flow was studied in heifers by transrectal color-Doppler ultrasound. Data were normalized to the decrease in plasma progesterone to <1 ng/ml (Day 0 or Hour 0). Blood flow in the corpus luteum (CL) was estimated by the percentage of CL area with color flow signals. Systemic prostaglandin F2alpha (PGF) treatment (25 mg; n=4) resulted in a transient increase in CL blood flow during the initial portion of the induced decrease in progesterone. Intrauterine treatment (1 or 2 mg) was done to preclude hypothetical secondary effects of systemic treatment. Heifers were grouped into responders (luteolysis; n=3) and nonresponders (n=5). Blood flow increased transiently in both groups; induction of increased blood flow did not assure the occurrence of luteolysis. A transient increase in CL blood flow was not detected in association with spontaneous luteolysis when examinations were done every 12 h (n=6) or 24 h (n=10). The role of PGF pulses was studied by examinations every hour during a 12-h window each day during expected spontaneous luteolysis. At least one pulse of 13,14-dihydro-15-keto-PGF2alpha (PGFM) was identified in each of six heifers during the luteolytic period (Hours -48 to -1). Blood flow increased (P<0.02) during the 3-h ascending portion of the PGFM pulse, remained elevated for 2 h after the PGFM peak, and then decreased (P<0.03) to baseline. Results supported the hypothesis that CL blood flow increased and decreased with individual PGFM pulses during spontaneous luteolysis. |
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Authors:
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O J Ginther; L A Silva; R R Araujo; M A Beg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-06 |
Journal Detail:
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Title: Biology of reproduction Volume: 76 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-21 Completed Date: 2007-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: United States |
Other Details:
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Languages: eng Pagination: 506-13 Citation Subset: IM |
Affiliation:
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Eutheria Foundation, Cross Plains, Wisconsin 53528, USA. ginther@svm.vetmed.wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Corpus Luteum / blood supply*, drug effects Dinoprost / analogs & derivatives*, blood, pharmacology Female Luteolysis / physiology* Ovulation Progesterone / blood Regional Blood Flow Ultrasonography, Doppler, Color |
| Chemical | |
Reg. No./Substance:
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27376-76-7/15-keto-13,14-dihydroprostaglandin F2alpha; 551-11-1/Dinoprost; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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