Document Detail


Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge.
MedLine Citation:
PMID:  12576414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exhaled nitric oxide (NO) levels are high in asthmatic subjects and increase with exacerbations. We hypothesized that higher levels of NO observed during asthma exacerbations are due to increased synthesis of NO. Exhaled NO and peak flows were measured in 11 asthmatic and 9 healthy control subjects before and after experimental asthmatic response induced by whole lung allergen challenge. Baseline peak flows of asthmatics were significantly lower than controls and decreased significantly immediately after challenge (P = 0.004). NO was measured by collecting exhaled breaths without breath hold (NO0) and after a 15-s breath hold (NO15). The rate of NO accumulation over time [parts/billion per second (ppb/s)] was calculated by DeltaNO/Deltat = (NO15 - NO0)/15, where Delta denotes a change and t is time. The NO accumulation rates in asthmatic and control subjects were similar at baseline; however, NO accumulation at 24 h increased threefold from baseline in asthmatic compared with control subjects (asthmatic subjects, 0.6 +/- 0.2 ppb/s; control subjects, 0.2 +/- 0.1 ppb/s; P = 0.01). Our study suggests that increased NO during an asthma exacerbation is due to increased synthesis, perhaps by increased expression of NO synthases.
Authors:
Sumita B Khatri; Jeffrey Hammel; Mani S Kavuru; Serpil C Erzurum; Raed A Dweik
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-02-07
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-09     Completed Date:  2004-02-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-40; discussion 435     Citation Subset:  IM    
Affiliation:
Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Allergens / pharmacology*
Asthma / metabolism*,  physiopathology*
Breath Tests
Bronchial Hyperreactivity / metabolism*,  physiopathology*
Female
Forced Expiratory Volume / physiology
Humans
Lung / metabolism*,  physiopathology*
Male
Middle Aged
Nitric Oxide / metabolism*,  physiology*
Peak Expiratory Flow Rate / physiology
Respiratory Function Tests
Skin Tests
Grant Support
ID/Acronym/Agency:
HL-04265/HL/NHLBI NIH HHS; HL-68863/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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