Document Detail


Temporal aspects of the effects of cooling on responses of single auditory nerve fibers.
MedLine Citation:
PMID:  9745957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During an investigation of the effects of cochlear cooling on frequency tuning and input/output relations of single auditory nerve fibers in gerbil (Ohlemiller and Siegel (1994) Hear. Res. 80, 174-190), cooling-related changes in post-stimulus time histogram (PSTH) shape and phase-locking to tonebursts were characterized in a small sample of neurons. Local cochlear cooling by 5-10 degrees C below normal core temperature did not alter overall PSTH shape, although some evidence was found for a reduction in the time constants of rapid and short term rate adaptation. The relative contributions of rapid and short term response components appeared unaltered. Effects of cooling on phase-locking were assessed by calculating the synchronization index for responses to intense ( > 70 dB SPL) tonebursts at 0.5, 1.0, and 2.0 kHz. Synchronization filter functions exhibited modest reductions in both magnitude and the upper frequency limit of phase-locking. The effects of cooling on the temporal character of responses appear distinct from those of a simple reduction in stimulus intensity. Results are interpreted in terms of cooling-related changes in responses of cochlear hair cells and afferent neurons, and suggest that temperature artifacts are unlikely to underlie reported species differences in PSTH shape and phase-locking.
Authors:
K K Ohlemiller; J H Siegel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  123     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-30     Completed Date:  1998-11-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  78-86     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. kohlemiller@cid.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Cochlea / physiology*
Cold Temperature*
Gerbillinae
Nerve Fibers / physiology*
Vestibulocochlear Nerve / physiology*
Grant Support
ID/Acronym/Agency:
DC00350/DC/NIDCD NIH HHS; MH09565/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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