Document Detail


Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams.
MedLine Citation:
PMID:  22537420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Examine temporal alterations in vascular angiotensin II receptors (AT(1)R and AT(2)R) and determine vascular response to angiotensin II in growth-restricted offspring.
STUDY DESIGN: Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared.
RESULTS: Prenatal protein restriction reprogrammed AT(1a)R messenger RNA expression in male rats' mesenteric arteries to cause 1.7- and 2.3-fold increases at 3 and 6 months of age associated with arterial pressure increases of 10 and 33 mm Hg, respectively; however, in female rats, increased AT(1a)R expression (2-fold) and arterial pressure (15 mm Hg) occurred only at 6 months. Prenatal protein restriction did not affect AT(2)R expression. Losartan abolished hypertension, suggesting that AT(1a)R plays a primary role in arterial pressure elevation. Vasoconstriction to angiotensin II was exaggerated in all protein-restricted offspring, with greater potency and efficacy in male rats.
CONCLUSION: Prenatal protein restriction increased vascular AT(1)R expression and vasoconstriction to angiotensin II, possibly contributing to programmed hypertension.
Authors:
Kunju Sathishkumar; Meena Balakrishnan; Vijayakumar Chinnathambi; Haijun Gao; Chandra Yallampalli
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-06
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  206     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-07-27     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507.e1-10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin II Type 1 Receptor Blockers / pharmacology
Animals
Biological Markers / metabolism
Blood Pressure / drug effects
Diet, Protein-Restricted / adverse effects*
Female
Hypertension / etiology*,  metabolism,  physiopathology
Losartan / pharmacology
Male
Mesenteric Arteries / metabolism,  physiopathology
Pregnancy
Prenatal Exposure Delayed Effects / etiology*,  metabolism,  physiopathology
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1 / metabolism*
Receptor, Angiotensin, Type 2 / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Sex Factors
Vasoconstriction / physiology*
Grant Support
ID/Acronym/Agency:
HL 58144/HL/NHLBI NIH HHS; HL102866/HL/NHLBI NIH HHS; R01 HD057013/HD/NICHD NIH HHS; R01 HD057013-01A2/HD/NICHD NIH HHS; R01 HL058144/HL/NHLBI NIH HHS; R01 HL058144-13/HL/NHLBI NIH HHS; R01 HL102866/HL/NHLBI NIH HHS; R01 HL102866-01A1/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Agtr1a protein, rat; 0/Angiotensin II Type 1 Receptor Blockers; 0/Biological Markers; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; JMS50MPO89/Losartan
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reproductive outcomes in women with classic bladder exstrophy: an observational cross-sectional stud...
Next Document:  Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the CHOIR (Cor...