Document Detail


Temporal alteration of serum G-CSF and VEGF levels in perinatal asphyxia treated with head cooling.
MedLine Citation:
PMID:  22944463     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: Granulocyte-colony stimulating factor (G-CSF) and vascular endothelial growth factor (VEGF) are thought to be associated with the pathophysiology of perinatal asphyxia. To clarify any such association, we analyzed the serum levels in neonates with perinatal asphyxia treated with head cooling. Study design: Temporal alterations of serum G-CSF and VEGF levels were measured within 24h of birth in five neonatal cases of severe asphyxia treated with head cooling, five neonatal cases without head cooling, and four healthy neonatal cases. Results: G-CSF in sera markedly increased and sustained in severely asphyxiated neonates treated with head cooling, while VEGF decreased and remained low. Conclusion: G-CSF and VEGF levels in sera might be associated with an early phase of brain protection after birth in severe asphyxia treated with head cooling.
Authors:
Kaoru Okazaki; Takashi Kusaka; Masatoshi Kondo; Kunihisa Kozawa; Masakazu Yoshizumi; Hirokazu Kimura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-31
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-9-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neonatology, Kagawa National Children's Hospital, 2603 Zentsuji, Zentsuji-shi, Kagawa 765-8501, Japan.
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