Document Detail

Temporal trends in survival to adulthood among patients born with congenital heart disease from 1970 to 1992 in Belgium.
MedLine Citation:
PMID:  21098444     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Over the past decades, the life expectancy of individuals with congenital heart disease (CHD) has increased significantly. However, precise estimates for survival to adulthood are scarce for patients with CHD. We investigated the proportion of CHD patients born between 1990 and 1992 who survived into adulthood. We also compared their survival with that of CHD patients born in earlier eras and evaluated survival as a function of the type of heart defect.
METHODS AND RESULTS: We reviewed the CHD program administrative and clinical database at the University Hospitals Leuven (Leuven, Belgium) and analyzed the records of 7497 CHD patients born from 1970 to 1992. Survival to 18 years of age in patients born between 1990 and 1992 was 88.6% (95% confidence interval [CI], 86.3% to 90.5%), which was significantly greater than that of patients born in previous decades (P<0.0001). For patients born between 1990 and 1992, survival into adulthood for those with mild heart defects was 98.0% (95% CI, 95.8% to 99.1%), whereas survival for those with moderate- and severe-complexity heart defects was 90.0% (95% CI, 86.8% to 92.5%) and 56.4% (95% CI, 47.4% to 64.5%), respectively. Analysis per heart defect confirmed these findings, demonstrating that patients with univentricular heart (49.1% [95% CI, 30.8% to 65.1%]) and hypoplastic left heart syndrome (7.5% [95% CI, 0.6% to 26.6%]) had the poorest survival rate.
CONCLUSION: This study demonstrates that almost 90% of children with CHD have the prospect of surviving into adulthood.
Philip Moons; Lore Bovijn; Werner Budts; Ann Belmans; Marc Gewillig
Related Documents :
18513824 - Phase ii study of combination chemotherapy with s-1 and weekly cisplatin in patients wi...
6687194 - Weekly cisplatin during cranial irradiation for malignant melanoma metastatic to brain.
21167654 - Imrt with simultaneous integrated boost and concurrent chemotherapy for locoregionally ...
23052174 - Anti-helicobacter pylori therapy in primary malt lymphoma of rectum.
10950004 - Is local excision adequate therapy for early rectal cancer?
24166914 - Anticipating the clinical use of prognostic gene expression-based tests for colon cance...
Publication Detail:
Type:  Journal Article     Date:  2010-11-22
Journal Detail:
Title:  Circulation     Volume:  122     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2264-72     Citation Subset:  AIM; IM    
Center for Health Services and Nursing Research, Katholieke Universiteit Leuven, Kapucijnenvoer 35, Post Box 7001, B-3000 Leuven, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Belgium / epidemiology
Child, Preschool
Heart Defects, Congenital / classification,  epidemiology*,  mortality*
Kaplan-Meier Estimate
Regression Analysis
Retrospective Studies
Severity of Illness Index
Survival Rate
Young Adult
Comment In:
Circulation. 2010 Nov 30;122(22):2231-3   [PMID:  21147727 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Myocardial infarction and risk of suicide: a population-based case-control study.
Next Document:  Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-te...