| Temporal trends in adherence to cardiovascular medications in elderly patients after hospitalization for heart failure. | |
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MedLine Citation:
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PMID: 20827266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the complexity of treatment regimens for patients with heart failure (HF) has increased over time because of the increased availability of efficacious medications, little is known about temporal trends in adherence to treatment regimens in these patients. We assessed trends in adherence to angiotensin-system blockers (ABs), β-blockers (BBs), and spironolactone (SL) for HF in Medicare beneficiaries enrolled in two statewide pharmacy benefit programs from 1995 to 2004. The proportion of days covered (PDC) (%) was assessed after the first dispensing among users of an AB, BB, or SL. Proportions of full adherence (PDC >80%) did not change over time for ABs (54% in both 1996 and 2003) but increased slightly for BBs (from 47% in 1996 to 57% in 2003) and SL (from 31% in 1996 to 42% in 2003). Black race and dialysis treatment predicted poor adherence to any medications. Adherence to BBs and SL increased modestly over time, but overall nonadherence remained high. |
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Authors:
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S Setoguchi; N K Choudhry; R Levin; W H Shrank; W C Winkelmayer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2010-09-08 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 88 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-20 Revised Date: 2011-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 548-54 Citation Subset: AIM; IM |
Affiliation:
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Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. ssetoguchi@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / therapeutic use Cardiovascular Agents / administration & dosage*, therapeutic use Cohort Studies Female Heart Failure / drug therapy* Humans Insurance Claim Review Male Medication Adherence / statistics & numerical data* Patient Discharge / statistics & numerical data* Socioeconomic Factors Spironolactone / therapeutic use Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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K02-HS017731/HS/AHRQ HHS; K23 HL090505-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiovascular Agents; 52-01-7/Spironolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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