Document Detail

Temporal expression of antioxidants in human cervicovaginal fluid associated with spontaneous labor.
MedLine Citation:
PMID:  20446766     Owner:  NLM     Status:  MEDLINE    
Proteomic analysis of human cervicovaginal fluid (CVF) by 2D electrophoresis revealed significant differential expression of several major antioxidant enzymes during late pregnancy and term labor. Temporal quantitative changes of total antioxidant capacity (TAC), Cu,Zn superoxide dismutase (Cu,Zn SOD) and thioredoxin-1 (Trx-1) with impending term labor were investigated, and the potential of these biomarkers as individual and multiple predictors of labor was determined. The TAC of CVF (n = 193) was 8-fold significantly lower in labor, and approximately 2-fold significantly lower at 0-7, 8-14, 15-21, and 22-28 days, compared with >or=29 days prior to labor onset (p < 0.001). The expression of Cu,Zn SOD (n = 170) was 1.5- to 1.9-fold significantly decreased in labor (p < 0.001). Trx-1 (n = 163) was 2.8- to 5.1-fold significantly lower in labor (p = 0.002). The combination of TAC and Cu,Zn SOD produced the best predictive efficacy with 74% sensitivity and 95% specificity to predict term labor within 3 days of onset. These findings suggest that labor is associated with increased oxidative stress well before its onset and is reflected in the human CVF. The biomarkers identified in this study could serve as predictors of labor and offer potential strategies for novel therapeutics.
Yujing Jan Heng; Megan Katherine Waterhouse Di Quinzio; Michael Permezel; Gregory Edward Rice; Harry Michael Georgiou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  13     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-20     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  951-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Melbourne, Parkville, Melbourne, Australia.
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MeSH Terms
Antioxidants / metabolism*
Body Fluids / enzymology,  metabolism
Cervix Mucus / metabolism*
Labor Onset / metabolism
Labor, Obstetric / metabolism*
Oxidative Stress
Superoxide Dismutase / metabolism
Thioredoxins / metabolism
Time Factors
Vagina / metabolism
Reg. No./Substance:
0/Antioxidants; 52500-60-4/Thioredoxins; EC Dismutase

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