| Temporal Changes in Renal Glomerular Function Associated with the use of Tenofovir Disoproxil Fumarate in HIV-Infected Nigerians. | |
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MedLine Citation:
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PMID: 22120479 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Reports of renal dysfunction in Tenofovir Disoproxil Fumarate (TDF)-treated HIV-1 infected patients have raised concerns about potential nephrotoxicity. Objective: To compare the effects on renal function of TDF-containing highly active anti-retroviral therapy (HAART) with a non-TDF-containing HAART. Methods: This was an observational study.Clinical and laboratory data of 186 HIV-1 infected adult Nigerians on first-line HAART for at least 48 weeks were reviewed. Eighty-four patients whose nucleos(t)ide reverse transcriptase inhibitor (NRTI) backbone included TDF were compared to 102 patients on other NRTI backbones. Creatinine clearance (CLcr) was estimated using the Cockcroft-Gault equation. Changes in serum creatinine and CLcr from the baseline for each patient were compared between the TDF-treated and the TDF-free patients. We also assessed the associations of other variables with change in CLcr... Results: Baseline median serum creatinine (mmol/L) was 77 and 84 in the TDF-treated and TDF-free groups, respectively (p=0.59). Baseline median CLcr (mls/min) was 83 in the TDF-treated patients vs 78 in the TDF-free group. At 48 weeks, serum creatinine increased by 18.1% and 1.2% in the TDF-treated and TDF-free arms, respectively. There was a decrease of 4.8% in GFR in the TDF arm compared to a gain 5.1% in the TDF-free arm. Conclusion: Tenofovir Disoproxil Fumarate-containing HAART is associated with a slight decline in the medium term in CLcr compared with HAART regimens containing alternative Nucleosid(t) Reverse Transcriptase Inhibitors. |
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Authors:
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O O Agbaji; P A Agaba; J A Idoko; B Taiwo; R Murphy; P Kanki; E Ekong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: West African journal of medicine Volume: 30 ISSN: 0189-160X ISO Abbreviation: West Afr J Med Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301891 Medline TA: West Afr J Med Country: Nigeria |
Other Details:
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Languages: eng Pagination: 164-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jos University Teaching Hospital, P.M.B. 2076, Jos, Nigeria. Email:oagbjai@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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