Document Detail

Temporal Association Between Rhinovirus Circulation in the Community and Invasive Pneumococcal Disease in Children.
MedLine Citation:
PMID:  21200362     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Mucosal coinfections with respiratory viruses and Streptococcus pneumoniae are common, but the role of rhinovirus infections in the development of invasive pneumococcal disease (IPD) in children has not been studied. METHODS:: During 1995 and 2007, we analyzed the association of IPD in children less than 5 years of age with respiratory virus epidemics by combining data from the National Infectious Disease Register, 3 prospective epidemiologic studies, and the database of the Department of Virology, University of Turku, Finland. RESULTS:: The mean IPD rate in children younger than 5 years of age in Finland was 2.9 cases per week (95% confidence interval [CI], 2.5-3.3) during periods of high rhinovirus activity, and 1.4 (95% CI, 1.2-1.6) during periods of low rhinovirus activity (P < 0.001). The IPD rate correlated with the rhinovirus activity recorded at the Department of Virology (correlation coefficient, 0.23; P = 0.001) and in the epidemiologic studies (correlation coefficients, 0.28, 0.25, and 0.31). The IPD rate was moderately increased during periods of high respiratory syncytial virus activity (mean, 2.1 cases per week; 95% CI, 1.8-2.3) compared with periods of low respiratory syncytial virus activity (mean, 1.7; 95% CI, 1.6-1.9; P = 0.008). There were no differences in the IPD rate between the periods of high and low influenza activity. CONCLUSIONS:: Rhinovirus circulation in the community had an association with IPD in children younger than 5 years of age. This study suggests that rhinovirus infection may be a contributor in the development of IPD in the population of young children.
Ville Peltola; Terho Heikkinen; Olli Ruuskanen; Tuomas Jartti; Tapani Hovi; Terhi Kilpi; Raija Vainionpää
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-30
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the *Department of Pediatrics, Turku University Hospital, Turku, Finland; †Turku Institute for Child and Youth Research, University of Turku, Turku, Finland; ‡Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland; and §Department of Virology, University of Turku, Turku,Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pneumococcal Nasopharyngeal Carriage Among Infants Born to Human Immunodeficiency Virus-infected Mot...
Next Document:  Perfusion storage reduces apoptosis in a porcine kidney model of donation after cardiac death.