Document Detail

Temperature- and salinity-decoupled overproduction of hydroxyectoine by Chromohalobacter salexigens.
MedLine Citation:
PMID:  23160137     Owner:  NLM     Status:  MEDLINE    
Hydroxyectoine overproduction by the natural producer Chromohalobacter salexigens is presented in this study. Genetically engineered strains were constructed that at low salinity coexpressed, in a vector derived from a native plasmid, the ectoine (ectABC) and hydroxyectoine (ectD) genes under the control of the ectA promoter, in a temperature-independent manner. Hydroxyectoine production was further improved by increasing the copies of ectD and using a C. salexigens genetic background unable to synthesize ectoines.
Javier Rodríguez-Moya; Montserrat Argandoña; Fernando Iglesias-Guerra; Joaquín J Nieto; Carmen Vargas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-16
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  79     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-06-10     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1018-23     Citation Subset:  IM    
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, Seville, Spain.
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MeSH Terms
Amino Acids, Diamino / metabolism*
Chromohalobacter / drug effects,  metabolism*,  radiation effects
Gene Dosage
Metabolic Engineering*
Metabolic Networks and Pathways / genetics*
Reg. No./Substance:
0/Amino Acids, Diamino; 0/hydroxyectoine

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