Document Detail

Temperature-modulated pressure ulcers: a porcine model.
MedLine Citation:
PMID:  7605187     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A reliable porcine model was developed to facilitate investigations of pressure ulcer formation, healing, and prevention. In the present study, it was specifically used to study the relationship between applied temperature, applied pressure, and time of application in the formation of cutaneous and deep tissue injuries. DESIGN: An apparatus and procedure were created to simultaneously apply 12 metal discs (each with a diameter of 51mm) on the dorsal aspect of the swine, all at an equal pressure of 100mmHg, for a 5-hour period, while servo-controlling disc temperatures at either 25, 35, 40, or 45 degrees C. RESULTS: The severity of the resultant tissue injuries correlated with an increase in applied temperature. No damage was observed in the superficial or deep tissues underlying the sites of the 25 degrees C pressure applicators. In general, only deep tissue damage resulted from the application of a 35 degrees C temperature, whereas the application of higher temperatures caused both cutaneous and subdermal damage (the extent of necrosis being greater at the 45 degrees C sites). There was a high degree of reproducibility of these results among a large population of sites per temperature (n = 64) and number of animals investigated (n = 16). Furthermore, subsequent healing (monitored up to 4 weeks) was uniform for the degree of induced damage. Insights into pressure ulcer formation were also sought via systematic examination of histological sides and postmortem visual assessment over the 4-week period. CONCLUSION: It was concluded that this animal model of temperature-modulated pressure ulcers has the potential for significant use in all major areas of this field, ie, wound formation, healing, and prevention.
J Y Kokate; K J Leland; A M Held; G L Hansen; G L Kveen; B A Johnson; M S Wilke; E M Sparrow; P A Iaizzo
Related Documents :
7877907 - Countertransference in the treatment of the borderline personality.
6526577 - Major amputation in paraplegic and tetraplegic patients.
1598737 - Mechanism preventing backflow from the canine corpora cavernosa to arteries in the rigi...
15568337 - Compatibility of an organically based insect control program with honey bee (hymenopter...
20409917 - Characteristics of inner-city african-americans with uncontrolled hypertension.
2240167 - Cyclocreatine inhibits the production of neutrophil chemotactic factors from isolated h...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  76     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  666-73     Citation Subset:  AIM; IM    
Department of Anesthesiology, University of Minnesota 55455, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Disease Models, Animal*
Pressure Ulcer / pathology,  physiopathology*
Reproducibility of Results
Skin / pathology
Skin Temperature
Wound Healing

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduction of spastic hypertonia in patients with spinal cord injury: a double-blind comparison of in...
Next Document:  Reduction in bowel program duration with polyethylene glycol based bisacodyl suppositories.