Document Detail

Temperature and isoproterenol modulation of beta-adrenergic receptor characteristics.
MedLine Citation:
PMID:  3003476     Owner:  NLM     Status:  MEDLINE    
Since agonists and temperature affect receptor affinity, and since these factors may influence the actual determination of receptor affinity, we assessed the in vitro effects of temperature and isoproterenol on the high and low affinity states of beta-adrenergic receptors in rat membrane preparations. There was a temperature-dependent decrease in beta-adrenergic receptor agonist affinity which was further promoted by the presence of isoproterenol. The decrease in receptor agonist affinity was reflected by a decrease in the number of receptors in the high affinity state. These data suggest that receptor desensitization may occur in membrane preparations in vitro and that the present methodology used to assess agonist affinity in vitro may itself alter the very properties being measured.
P J Scarpace; S W O'Connor; I B Abrass
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  38     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-26     Completed Date:  1986-02-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
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MeSH Terms
Binding, Competitive
Cell Membrane / metabolism
Cold Temperature*
Dihydroalprenolol / metabolism
Isoproterenol / metabolism,  pharmacology*
Lung / metabolism*
Propanolamines / pharmacology
Receptors, Adrenergic, beta / drug effects,  metabolism*
Reg. No./Substance:
0/Propanolamines; 0/Receptors, Adrenergic, beta; 42200-33-9/Nadolol; 60106-89-0/Dihydroalprenolol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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