Document Detail

Temperature-dependent specificity of cis-trans isomeric fatty acid interaction with the erythrocyte membrane.
MedLine Citation:
PMID:  3955039     Owner:  NLM     Status:  MEDLINE    
Stabilization of red cells against hypotonic haemolysis by cis-trans isomeric free C18 fatty acids occurs with pronounced specificity which is strongly temperature-dependent, but in a distinctly different manner for the two configurational isomers. Oleic acid (cis-18:1) stabilizes very efficiently at 0 degrees C, even at the highest concentrations. Elaidic acid (trans-18:1) causes neither stabilization nor haemolysis at this temperature. At room temperature (23 degrees C), elaidic acid acquires the ability to protect, without turning haemolytic at high concentrations. At 37 degrees C elaidic acid also becomes haemolytic. The protecting effect of oleic acid at 0 degrees C is the result of a rapid reaction. The characteristic, temperature-dependent specificity of cis-trans isomeric C18 fatty acid interaction with the red cell membrane appears to be a general phenomenon, since it was observed alike with erythrocytes of different species.
A Csordas; K Schauenstein
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  856     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-15     Completed Date:  1986-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  212-8     Citation Subset:  IM    
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MeSH Terms
Erythrocyte Membrane / drug effects,  ultrastructure*
Fatty Acids, Nonesterified / pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Fatty Acids, Nonesterified

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