Document Detail


Temperature dependence of the 31P chemical shifts of nucleic acids. A prode of phosphate ester torsional conformations.
MedLine Citation:
PMID:  952888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The temperature dependence of the 31P chemical shifts of the ribodinucleoside monophosphates, ApA, GpC, CpC, UpU, and ApU, of the deoxyribonucleic acids, d-ApT, TpT, d-ApA, and d-pApT, and of the homopolyribonucleic acids poly(G), poly(U), poly(A) is shown to provide information on the helix-coli transition in nucleic acids. The base stacked, helical structure with a gauche,gauche phosphate ester torsional conformation is 0.2-0.6 ppm upfield from the random coil conformation. In contrast, the 31P chemical shifts of dimethyl and diethyl phosphate do not change significantly with temperature. These results support our earlier hypothesis that 31P shifts are sensitive probes of torsional conformations with phosphate esters in gauche,gauche conformations having 31P shifts upfield from nongauche conformations.
Authors:
D G Gorenstein; J B Findlay; R K Momii; B A Luxon; D Kar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  15     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3796-803     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Deoxyribonucleotides
Magnetic Resonance Spectroscopy
Nucleic Acid Conformation
Nucleic Acids*
Nucleotides
Organophosphorus Compounds*
Phosphoric Acid Esters*
Polynucleotides
Temperature
Chemical
Reg. No./Substance:
0/Deoxyribonucleotides; 0/Nucleic Acids; 0/Nucleotides; 0/Organophosphorus Compounds; 0/Phosphoric Acid Esters; 0/Polynucleotides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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