| Temperature change-induced potentiation: a comparative study of facilitatory mechanisms in aged and young rat hippocampal slices. | |
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MedLine Citation:
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PMID: 7477949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of temperature changes in the medium on the evoked potentials of pyramidal neurons in response to the electrical stimulation of Schaffer collaterals was investigated in both young (one to two months) and aged (24-28 months) rat hippocampal slices. Temperature increase was shown to reduce, and subsequent temperature decrease to enhance, the population spike amplitude in both young and aged rats. Temperature decrease produced a long-lasting (> 30 min) and important potentiation (180%) of population spike amplitude in young but not in aged rats. Long-term post-tetanic potentiation was maintained in young but suppressed in aged rats by temperature changes. The impairment of temperature-induced potentiation in aged rats is suggested as a tool for studying promnesic drugs. |
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Authors:
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S Buldakova; E Dutova; S Ivlev; M Weiss |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience Volume: 68 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 395-7 Citation Subset: IM |
Affiliation:
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I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Cold Temperature Electric Stimulation Hippocampus / physiology* Long-Term Potentiation / physiology* Pyramidal Cells / physiology Rats Rats, Wistar Temperature |
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