Document Detail

Temperature can alter the function outcome of spinal cord regeneration in larval lampreys.
MedLine Citation:
PMID:  10218795     Owner:  NLM     Status:  MEDLINE    
Now that spinal cord regeneration has been demonstrated in mammals [Bregman B. S. et al. (1995) Nature 378, 498-501; Cheng H. et al. (1996) Science 273, 510-513], we must examine the consequences and look for means of avoiding negative outcomes. The larval lamprey, which readily regenerates cut spinal axons, offers a model for this important next step. In the present study, one group of larval lampreys with spinal lesions was kept at room temperature during recovery. Another group was returned to their usual cold room temperature. A majority of animals kept at room temperature recovered full locomotor behavioral function, while a majority of those that recovered at a colder temperature exhibited dysfunctional locomotor behavior. The dysfunction most often consisted of segments rostral and caudal to the lesion site lacking the usual coordination and apparently interfering with each. In both groups, there was a close association between the presence of dysfunction and the quality of the intersegmental coordination as assessed in the isolated spinal cord preparation. These results suggest that a relatively minor difference in conditions under which an animal recovers may drastically alter the likelihood of a favorable functional outcome.
A H Cohen; T Kiemel; V Pate; J Blinder; L Guan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  90     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-14     Completed Date:  1999-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  957-65     Citation Subset:  IM    
Department of Zoology, University of Maryland, College Park 20742, USA.
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MeSH Terms
Lampreys / growth & development,  physiology*
Larva / physiology
Motor Activity / physiology
Nerve Regeneration / physiology*
Spinal Cord / physiopathology*
Grant Support

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