Document Detail

Temperature can alter the function outcome of spinal cord regeneration in larval lampreys.
MedLine Citation:
PMID:  10218795     Owner:  NLM     Status:  MEDLINE    
Now that spinal cord regeneration has been demonstrated in mammals [Bregman B. S. et al. (1995) Nature 378, 498-501; Cheng H. et al. (1996) Science 273, 510-513], we must examine the consequences and look for means of avoiding negative outcomes. The larval lamprey, which readily regenerates cut spinal axons, offers a model for this important next step. In the present study, one group of larval lampreys with spinal lesions was kept at room temperature during recovery. Another group was returned to their usual cold room temperature. A majority of animals kept at room temperature recovered full locomotor behavioral function, while a majority of those that recovered at a colder temperature exhibited dysfunctional locomotor behavior. The dysfunction most often consisted of segments rostral and caudal to the lesion site lacking the usual coordination and apparently interfering with each. In both groups, there was a close association between the presence of dysfunction and the quality of the intersegmental coordination as assessed in the isolated spinal cord preparation. These results suggest that a relatively minor difference in conditions under which an animal recovers may drastically alter the likelihood of a favorable functional outcome.
A H Cohen; T Kiemel; V Pate; J Blinder; L Guan
Related Documents :
21702465 - Highly-loaded silicone nanocomposite exhibiting quick thermo-responsive optical behavior.
23256755 - Well defined micro-apertures for ion channel biosensors.
23178595 - Sphingomyelin organization is required for vesicle biogenesis at the golgi complex.
21774485 - Reversible redox of nadh and nad+ at a hybrid lipid bilayer membrane using ubiquinone.
6463425 - The design and the role of the nasal passages in temperature regulation in the dik-dik ...
20819385 - Short-term storage and transport at cold temperatures of 2-cell mouse embryos produced ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience     Volume:  90     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-14     Completed Date:  1999-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  957-65     Citation Subset:  IM    
Department of Zoology, University of Maryland, College Park 20742, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Lampreys / growth & development,  physiology*
Larva / physiology
Motor Activity / physiology
Nerve Regeneration / physiology*
Spinal Cord / physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prolonged exposure to elevated levels of endogenous nerve growth factor affects the morphological an...
Next Document:  Effects of serotonin on neurite outgrowth from thalamic neurons in vitro.