| Temperature can alter the function outcome of spinal cord regeneration in larval lampreys. | |
| | |
MedLine Citation:
|
PMID: 10218795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Now that spinal cord regeneration has been demonstrated in mammals [Bregman B. S. et al. (1995) Nature 378, 498-501; Cheng H. et al. (1996) Science 273, 510-513], we must examine the consequences and look for means of avoiding negative outcomes. The larval lamprey, which readily regenerates cut spinal axons, offers a model for this important next step. In the present study, one group of larval lampreys with spinal lesions was kept at room temperature during recovery. Another group was returned to their usual cold room temperature. A majority of animals kept at room temperature recovered full locomotor behavioral function, while a majority of those that recovered at a colder temperature exhibited dysfunctional locomotor behavior. The dysfunction most often consisted of segments rostral and caudal to the lesion site lacking the usual coordination and apparently interfering with each. In both groups, there was a close association between the presence of dysfunction and the quality of the intersegmental coordination as assessed in the isolated spinal cord preparation. These results suggest that a relatively minor difference in conditions under which an animal recovers may drastically alter the likelihood of a favorable functional outcome. |
| | |
Authors:
|
A H Cohen; T Kiemel; V Pate; J Blinder; L Guan |
Related Documents
:
|
21702465 - Highly-loaded silicone nanocomposite exhibiting quick thermo-responsive optical behavior. 23256755 - Well defined micro-apertures for ion channel biosensors. 23178595 - Sphingomyelin organization is required for vesicle biogenesis at the golgi complex. 21774485 - Reversible redox of nadh and nad+ at a hybrid lipid bilayer membrane using ubiquinone. 6463425 - The design and the role of the nasal passages in temperature regulation in the dik-dik ... 20819385 - Short-term storage and transport at cold temperatures of 2-cell mouse embryos produced ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Neuroscience Volume: 90 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 1999 Mar |
Date Detail:
|
Created Date: 1999-06-14 Completed Date: 1999-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 957-65 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of Maryland, College Park 20742, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Axotomy Electromyography Lampreys / growth & development, physiology* Larva / physiology Motor Activity / physiology Nerve Regeneration / physiology* Spinal Cord / physiopathology* Temperature* |
| Grant Support | |
ID/Acronym/Agency:
|
NS16803/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prolonged exposure to elevated levels of endogenous nerve growth factor affects the morphological an...
Next Document: Effects of serotonin on neurite outgrowth from thalamic neurons in vitro.