Document Detail


Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids.
MedLine Citation:
PMID:  9274864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examines the changes in cellular lipids that take place when Trypanosoma cruzi epimastigotes and metacyclic trypomastigotes are transferred from 28 to 37 degrees C. We found a rise in the sterol to phospholipid ratio, as well as in the triacylglycerol and steryl ester cellular content in T. cruzi epimastigotes. In addition, saturated to unsaturated fatty acid ratios in phospholipids increase. This latter effect appears to be due to two concurrent processes. Firstly, fatty acyl delta9 and, especially, delta12 desaturations are significantly diminished at 37 degrees C. Secondly, triacylglycerols and steryl esters undergo changes in their fatty acyl composition opposite to those simultaneously observed in phospholipids, i.e. the ratio of saturated to unsaturated fatty acids markedly decreases. Similar alterations in each of the lipid classes and in the fatty acid composition of polar and neutral lipids were found in cultured metacyclic trypomastigotes on exposure to the same shift-up. These observations suggest that a global remodeling of cellular lipids that involves extensive fatty acid exchange between neutral and polar lipid pools represents a novel and important mechanism of adaptation of the parasites to the temperature changes they encounter in their life cycle.
Authors:
M Florin-Christensen; J Florin-Christensen; E D de Isola; E Lammel; E Meinardi; R R Brenner; L Rasmussen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  88     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-33     Citation Subset:  IM    
Affiliation:
Institute of Neuroscience (INEUCI), CONICET-UBA, Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina. florin@biolo.bg.fcen.uba.ar
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Fatty Acid Desaturases / metabolism
Fatty Acids / analysis
Lipid Metabolism*
Lipids / chemistry
Phospholipids / chemistry,  metabolism
Sterols / chemistry,  metabolism
Temperature
Triglycerides / chemistry,  metabolism
Trypanosoma cruzi / growth & development,  metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Phospholipids; 0/Sterols; 0/Triglycerides; EC 1.14.19.-/Fatty Acid Desaturases

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