| Temperature isotherms during pulmonary cryoablation and their correlation with the zone of ablation. | |
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MedLine Citation:
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PMID: 20688532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the expected ablation zone size and associated isotherms when using clinically available percutaneous cryoprobes for pulmonary cryoablation in a porcine lung model. MATERIALS AND METHODS: Seven ablations were performed in the lungs of three adult pigs using clinically available 2.4-mm cryoprobes (Endocare, Inc, Irvine, California) and a 10-minute double-freeze protocol. Five 18-gauge thermocouples were positioned at 5-mm increments (ie, 5, 10, 15, 20, and 25 mm) from the cryoprobe. Real-time tissue temperatures were recorded during the cryoablation. The isotherms obtained during the ablation and the pathological ablation zones were measured. RESULTS: The pathologic zone of complete necrosis had a mean diameter of 2.4 + or - 0.2 cm, with a mean area of 4.6 + or - 0.6 cm(2) and a circularity of 0.95 + or - 0.04. In comparison, the mean diameter (+ or - standard deviation) of the 0 degrees C, -20 degrees C, and -40 degrees C isotherms were 3.1 + or - 0.2 cm, 2.3 + or - 0.3 cm, and 1.8 + or - 0.4 cm, respectively. The -20 degrees C isotherm was most closely related to the pathologic zone of ablation. CONCLUSIONS: This study establishes the temperature isotherms and associated ablation zone size that can be expected with modern percutaneous cryoprobes in an in vivo porcine lung model. |
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Authors:
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J Louis Hinshaw; Fred T Lee; Paul F Laeseke; Lisa A Sampson; Christopher Brace |
Publication Detail:
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Type: Journal Article Date: 2010-08-04 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1424-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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University of Wisconsin Department of Radiology, E3/311 CSC, 600 Highland Avenue, Madison, WI 53792, USA. jhinshaw@uwhealth.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cold Temperature* Cryosurgery* / instrumentation Equipment Design Female Lung / pathology, surgery* Models, Animal Necrosis Sus scrofa Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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L30 CA136262-01/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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