Document Detail

Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949.
MedLine Citation:
PMID:  9040286     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Temperance boards were established in Sweden to register and follow up individuals who were seen in legal or medical settings with problems of alcohol abuse. These records, available in a large epidemiologic twin population, have provided an objective and validated measure of alcohol abuse. METHODS: We examined Swedish temperance board registrations from 1929 to 1974 (n = 2516 individual twins) in all male-male Swedish twin pairs of known zygosity from the population-based Swedish Twin Registry; these twin pairs were born from 1902 to 1949 (n = 8935 pairs). RESULTS: The lifetime prevalence and probandwise concordance rates for temperance board registrations were 13.2% and 47.9%, respectively, in monozygotic twins and 14.6% and 32.8%, respectively, in dizygotic twins. Model fitting suggested that genetic and familial-environmental risk factors accounted for 54% (95% confidence interval [CI], 47%-61%) and 14% (95% CI, 8%-19%) of the liability to temperance board registration, respectively; these estimates were stable across birth cohorts. High genetic liability was reflected by large numbers of temperance board registrations and registrations for criminal alcohol use. Elevated familial-environmental liability was indicated by an early age at first registration. CONCLUSIONS: Genetic factors are of major etiologic importance for alcohol abuse in men, while familial environmental factors play a significant but less important role. The etiologic importance of these factors has remained constant in Sweden for men who were born in the first half of the 20th century.
K S Kendler; C A Prescott; M C Neale; N L Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  54     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-84     Citation Subset:  AIM; IM    
Department of Psychiatry Medical College of Virginia/Virginia Commonwealth University, Richmond, USA.
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MeSH Terms
Age Factors
Alcoholism / epidemiology*,  genetics*
Cohort Studies
Confidence Intervals
Diseases in Twins / epidemiology*,  genetics*
Proportional Hazards Models
Registries / statistics & numerical data
Risk Factors
Sweden / epidemiology
Temperance / statistics & numerical data*
Twins, Dizygotic / statistics & numerical data
Twins, Monozygotic / statistics & numerical data
Grant Support

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