| Temozolomide-induced shrinkage of a pituitary carcinoma causing Cushing's disease--report of a case and literature review. | |
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MedLine Citation:
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PMID: 21057727 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Temozolomide (TMZ) is an alkylating chemotherapeutic agent that has recently been used in some cases as a new therapeutic tool for pituitary carcinomas and aggressive pituitary adenomas. In this report, we present the case of effective TMZ treatment in a 42-year-old man with ACTH-secreting carcinoma. The tumor grew progressively over 4 years, from 2.2 to 31.1 cm³, despite three surgical approaches and γ-knife treatment. Ki-67 increased from 2 to 18%. An intradural metastasis at the foramen magnum was detected by MRI after the third operation. Thereafter, four cycles of 5-day TMZ administration (200 mg/m²/day during the first, and 150 mg/m²/day during the following cycles) induced dramatic tumor size reduction (>90%). Clinical conditions improved progressively and, after 17 months from the beginning of TMZ administration, the patient is still alive. The treatment was well tolerated except for a transient thrombocytopenia (grade 4 WHO). |
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Authors:
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Lorenzo Curtò; Maria L Torre; Francesco Ferraù; Vincenzo Pitini; Giuseppe Altavilla; Francesca Granata; Marcello Longo; Leo J Hofland; Francesco Trimarchi; Salvatore Cannavò |
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Publication Detail:
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Type: Journal Article Date: 2010-11-04 |
Journal Detail:
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Title: TheScientificWorldJournal Volume: 10 ISSN: 1537-744X ISO Abbreviation: ScientificWorldJournal Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101131163 Medline TA: ScientificWorldJournal Country: England |
Other Details:
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Languages: eng Pagination: 2132-8 Citation Subset: IM |
Affiliation:
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Department of Medicine and Pharmacology, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands. curto.loren@libero.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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