Document Detail

Temozolomide-induced shrinkage of a pituitary carcinoma causing Cushing's disease--report of a case and literature review.
MedLine Citation:
PMID:  21057727     Owner:  NLM     Status:  In-Process    
Temozolomide (TMZ) is an alkylating chemotherapeutic agent that has recently been used in some cases as a new therapeutic tool for pituitary carcinomas and aggressive pituitary adenomas. In this report, we present the case of effective TMZ treatment in a 42-year-old man with ACTH-secreting carcinoma. The tumor grew progressively over 4 years, from 2.2 to 31.1 cm³, despite three surgical approaches and γ-knife treatment. Ki-67 increased from 2 to 18%. An intradural metastasis at the foramen magnum was detected by MRI after the third operation. Thereafter, four cycles of 5-day TMZ administration (200 mg/m²/day during the first, and 150 mg/m²/day during the following cycles) induced dramatic tumor size reduction (>90%). Clinical conditions improved progressively and, after 17 months from the beginning of TMZ administration, the patient is still alive. The treatment was well tolerated except for a transient thrombocytopenia (grade 4 WHO).
Lorenzo Curtò; Maria L Torre; Francesco Ferraù; Vincenzo Pitini; Giuseppe Altavilla; Francesca Granata; Marcello Longo; Leo J Hofland; Francesco Trimarchi; Salvatore Cannavò
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Publication Detail:
Type:  Journal Article     Date:  2010-11-04
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  10     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  2132-8     Citation Subset:  IM    
Department of Medicine and Pharmacology, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands.
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