Document Detail


Telomeric sequences, radiation sensitivity and genomic instability.
MedLine Citation:
PMID:  11682005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To review the basic features of telomeres with particular emphasis on their potential importance in radiation biology. Recent findings suggest that telomere length can influence radiation sensitivity in mouse and that several human radiosensitive disorders also show abnormalities in telomere dynamics. Numerous studies indicate that telomeric sequences may play a role in determining the stability of certain genomic regions both spontaneously and following irradiation. Furthermore, a number of transmissible genomic instability systems have been described in which it appears that telomere metabolism may be contributing to the delayed effects observed. Features of telomeres and telomere biology relevant to these topics are reviewed.
CONCLUSIONS: The evidence that telomeres and the molecular pathways of telomere maintenance can play a role in determining the outcome of radiation exposure is now substantial. Thus, the field of telomere biology deserves continued attention from radiobiologists.
Authors:
S D Bouffler; M A Blasco; R Cox; P J Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of radiation biology     Volume:  77     ISSN:  0955-3002     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-29     Completed Date:  2001-12-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  995-1005     Citation Subset:  IM; S    
Affiliation:
Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, OX11 ORQ, UK. simon.bouffler@nrpb.org.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations*
Chromosome Disorders*
Enzyme Induction / radiation effects
Humans
Neoplasms, Radiation-Induced / etiology
Radiation Tolerance*
Telomerase / biosynthesis
Telomere / physiology*
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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