| Telomeric sequences, radiation sensitivity and genomic instability. | |
| | |
MedLine Citation:
|
PMID: 11682005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To review the basic features of telomeres with particular emphasis on their potential importance in radiation biology. Recent findings suggest that telomere length can influence radiation sensitivity in mouse and that several human radiosensitive disorders also show abnormalities in telomere dynamics. Numerous studies indicate that telomeric sequences may play a role in determining the stability of certain genomic regions both spontaneously and following irradiation. Furthermore, a number of transmissible genomic instability systems have been described in which it appears that telomere metabolism may be contributing to the delayed effects observed. Features of telomeres and telomere biology relevant to these topics are reviewed. CONCLUSIONS: The evidence that telomeres and the molecular pathways of telomere maintenance can play a role in determining the outcome of radiation exposure is now substantial. Thus, the field of telomere biology deserves continued attention from radiobiologists. |
| | |
Authors:
|
S D Bouffler; M A Blasco; R Cox; P J Smith |
Related Documents
:
|
14580855 - New trends in bioinformatics: from genome sequence to personalized medicine. 11336835 - The meaning and impact of the human genome sequence for microbiology. 15992025 - Functional genomics conference: from identifying proteins to faster drug discovery. mar... 17407125 - A genomic screening approach to the structure-guided identification of drug candidates ... 11847285 - Short-chain dehydrogenase/reductase (sdr) relationships: a large family with eight clus... 8401585 - Rapid cdna sequencing (expressed sequence tags) from a directionally cloned human infan... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: International journal of radiation biology Volume: 77 ISSN: 0955-3002 ISO Abbreviation: Int. J. Radiat. Biol. Publication Date: 2001 Oct |
Date Detail:
|
Created Date: 2001-10-29 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8809243 Medline TA: Int J Radiat Biol Country: England |
Other Details:
|
Languages: eng Pagination: 995-1005 Citation Subset: IM; S |
Affiliation:
|
Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, OX11 ORQ, UK. simon.bouffler@nrpb.org.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chromosome Aberrations* Chromosome Disorders* Enzyme Induction / radiation effects Humans Neoplasms, Radiation-Induced / etiology Radiation Tolerance* Telomerase / biosynthesis Telomere / physiology* |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Some proposals for anaerobic primary culture from the supply side
Next Document: Proliferating cell nuclear antigen (PCNA): ringmaster of the genome.