Document Detail


Telomeric repeat sequences.
MedLine Citation:
PMID:  7924617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromosomes not only carry transcribed genes and their regulatory DNA sequences, but also contain regions that are required for the stability and maintenance of the chromosome as a unit. These include centromeres, telomeres and origins of replication. It is clear for replication origins and centromeres that the positions of these chromosomal organelles are determined by sites of the appropriate DNA sequences, but also that functional performance requires one or more contributing proteins. Telomeres are also structurally complex, with one or more DNA components, including simple telomeric repeats and more complex telomere-associated sequences, as well as one or more specific proteins that recognize these sequences. Accumulating evidence suggests that the simple telomeric repeats are required in most, but not all species, although they are not sufficient to determine the chromosomal position of a telomere.
Authors:
H Biessmann; J M Mason
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chromosoma     Volume:  103     ISSN:  0009-5915     ISO Abbreviation:  Chromosoma     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-10     Completed Date:  1994-11-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Affiliation:
Developmental Biology Center, University of California, Irvine 92717.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Models, Genetic
Repetitive Sequences, Nucleic Acid / physiology*
Telomere / physiology*
Grant Support
ID/Acronym/Agency:
GM46211/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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