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Telomeric length variation in human testicular germ cell tumours.
MedLine Citation:
PMID:  21590204     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Telomeric length was studied in 5 cases of human testicular germ cell rumours by measuring the length of the terminal restriction fragments (TRFs) containing the (TTAGCG)(n) sequence. Mean TRF length in human placenta used as a source of reference DNA for assessing the effect of cellular ageing was 14 kbp. TRF length in two classical seminomas and a mixed embryonal carcinoma/atypical seminoma ranged from 4 to 14 kbp and from 4 to 23 kbp, respectively, with the same mean value of 9 kbp in both tumour types. In a mixed teratoma/embryonal carcinoma, telomeric length ranged from 14 to 27 kbp with a mean of 20 kbp. In the single case of spermatocytic seminoma studied, telomeric length was up to 100 kbp with a distinct sharp band at similar to 50 kbp, representing the longest, homogeneous telomeres found so far.
Authors:
R Nowak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  4     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    1997 Sep-Oct
Date Detail:
Created Date:  2011-05-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1099-101     Citation Subset:  -    
Affiliation:
INST ONCOL,PL-02781 WARSAW,POLAND.
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