Document Detail

Telomeres, telomerase, and the cell cycle.
MedLine Citation:
PMID:  9552395     Owner:  NLM     Status:  MEDLINE    
Telomeres protect the ends of chromosomes from degradation and fusion. In most eukaryotes telomeres are replicated by a specialised polymerase, telomerase. Telomerase synthesises one strand of the telomere; while conventional DNA polymerases synthesise the complementary strand. Additional processing of telomeres occurs in ciliates and yeast during each cell cycle. Telomerase activity and RNA levels change as cells enter and exit the cell cycle. Gradual telomere shortening in the absence of telomerase does not immediately affect cell cycling; however, "critically" short telomeres are hypothesised to play a role in senescence and the triggering of DNA damage checkpoints.
K J Buchkovich
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cell cycle research     Volume:  2     ISSN:  1087-2957     ISO Abbreviation:  Prog Cell Cycle Res     Publication Date:  1996  
Date Detail:
Created Date:  1998-05-13     Completed Date:  1998-05-13     Revised Date:  2008-11-17    
Medline Journal Info:
Nlm Unique ID:  9609058     Medline TA:  Prog Cell Cycle Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
University of Illinois at Chicago, Department of Pharmacology, Chicago 60612, USA.
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MeSH Terms
Cell Aging
Cell Cycle / physiology*
Cell Division
DNA Damage
DNA Replication
Models, Biological
Telomerase / physiology*
Telomere / physiology*
Reg. No./Substance:

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