| Telomeres, telomerase, and apoptosis. | |
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MedLine Citation:
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PMID: 15284903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomeres are specialized high-order chromatin structures that cap the ends of eukaryotic chromosomes. In vertebrates, telomeric DNA is composed of repetitions of the TTAGGG hexanucleotide, is bound to a set of specific proteins, and is elongated by the reverse transcriptase enzyme telomerase. Telomerase activity is promptly detected in cells with an indefinite replicative potential, such as cancer cells, while is almost undetectable in normal cells, which are characterized by a limited life span. Mounting evidence indicates that the maintenance of telomere integrity and telomerase protect cells from apoptosis. Disruption of the telomere capping function and (or) telomerase inhibition elicit an apoptotic response in cancer cells, while restoration of telomerase activity in somatic cells confers resistance to apoptosis. The possible mechanisms linking telomeres, telomerase and apoptosis are discussed in this review, together with the impact of this field in anticancer research. |
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Authors:
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Chiara Mondello; A Ivana Scovassi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemistry and cell biology = Biochimie et biologie cellulaire Volume: 82 ISSN: 0829-8211 ISO Abbreviation: Biochem. Cell Biol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-30 Completed Date: 2005-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8606068 Medline TA: Biochem Cell Biol Country: Canada |
Other Details:
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Languages: eng Pagination: 498-507 Citation Subset: IM |
Affiliation:
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Istituto di Genetica Molecolare CNR, Pavia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Chromatin / physiology DNA / chemistry DNA-Binding Proteins Humans Mice Mice, Knockout Models, Biological Neoplasms / pathology Nucleotides / chemistry Telomerase / genetics, physiology* Telomere / ultrastructure* |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/DNA-Binding Proteins; 0/Nucleotides; 9007-49-2/DNA; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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