| Telomeres, senescence and cellular radiation response. | |
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MedLine Citation:
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PMID: 9284959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomeres shield the ends of chromosomes from degradation and end-to-end fusions. They shorten at each cell division and when they reach a critically short length, cells arrest in the G1 phase of the cell cycle and undergo senescence. This effectively limits the proliferative potential of cells. Senescence functions as a tumour suppressor mechanism and appears to contribute to the process of ageing. If senescence is circumvented by tumour viruses, proliferation is re-initiated until cells enter crisis. Activation of telomerase prevents telomere attrition and cells become immortal. Cellular response to ionizing radiation involves induction of cell cycle checkpoint arrests and programmed cell death. Because radiation produces double strand breaks in DNA, which cause telomere-less chromosome ends, radiation response appears to be the result of inappropriate induction of cellular senescence mechanisms. |
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Authors:
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N E Crompton |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 53 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-01 Completed Date: 1997-10-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 568-75 Citation Subset: IM |
Affiliation:
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Institute of Medical Radiobiology, Villigen-PSI, Switzerland. crompton@psi.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cell Aging* Cell Cycle / radiation effects Cell Transformation, Neoplastic DNA Damage DNA Replication Enzyme Activation Oncogenic Viruses / physiology Radiation, Ionizing* Signal Transduction Telomerase / metabolism Telomere / physiology*, radiation effects* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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