| Telomeres in T and B cells. | |
| | |
MedLine Citation:
|
PMID: 12209138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Telomeres are the structures at the ends of linear chromosomes. In mammalian cells, they consist of hexanucleotide (TTAGGG) repeats, together with many associated proteins. In the absence of a compensatory mechanism, dividing cells undergo gradual telomere erosion until a critical degree of shortening results in chromosomal abnormalities and cell death or senescence. For T and B cells, the ability to undergo extensive cell division and clonal expansion is crucial for effective immune function. This article describes our current understanding of telomere-length regulation in lymphocytes and its implications for immune function. |
| | |
Authors:
|
Richard J Hodes; Karen S Hathcock; Nan-ping Weng |
Related Documents
:
|
9571198 - Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial c... 15604268 - Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. 16123538 - Mosaicism of the retinal pigment epithelium: seeing the small picture. 10411308 - Loss of several cell functions including okadaic acid-induced apoptosis after multiple ... 6301868 - Topographical distribution of a membrane-inserted fluorescent phospholipid analogue dur... 178048 - Changes in the surface of virus-induced cells recognized by cytotoxic t cells. i. minim... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Review |
Journal Detail:
|
Title: Nature reviews. Immunology Volume: 2 ISSN: 1474-1733 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-09-04 Completed Date: 2002-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 699-706 Citation Subset: IM |
Affiliation:
|
National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. Richard_Hodes@nih.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging Animals B-Lymphocytes / cytology, immunology*, ultrastructure Cell Division Hematopoietic Stem Cells / cytology, immunology, ultrastructure Humans Immunity, Active Lymphocyte Activation T-Lymphocytes / cytology, immunology*, ultrastructure Telomerase / analysis, biosynthesis, genetics Telomere / chemistry, immunology* |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative analyses of immunoglobulin genes: surprises and portents.
Next Document: Antibodies, viruses and vaccines.