| Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR). | |
| | |
MedLine Citation:
|
PMID: 20619976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Telomeres are nucleoprotein structures located at the termini of chromosomes, and protect them from fusion and degradation. Telomeres are progressively shortened with each mitotic cycle and by environmental factors. We hypothesized that antepartum stress can lead to accelerated telomere shortening in placental trophoblasts, and plays a role in intrauterine growth restriction (IUGR). METHODS: Placental biopsies were derived from 16 pregnancies complicated with IUGR and from 13 uncomplicated pregnancies. Fluorescence-in-situ protocol was used to determine telomere length. Immunohistochemistry for hTERT was performed to assess telomerase activity. Clinical and histopathological characteristics were collected to ensure that IUGR was secondary to placental insufficiency. Fluorescence-in-situ-hybridization was used to rule out aneuploidy as a reason for shortened telomeres. RESULTS: The number and intensity of telomeres staining and telomerase activity were significantly lower in the IUGR placentas. No aneuploidy was detected for the chromosomes checked in the placental biopsies. CONCLUSIONS: Telomeres are shorter in trophoblasts of IUGR placentas. |
| | |
Authors:
|
Tal Biron-Shental; Rivka Sukenik Halevy; Lilach Goldberg-Bittman; Dvora Kidron; Moshe D Fejgin; Aliza Amiel |
Related Documents
:
|
20304486 - Expression of at1r, at2r and at4r and their roles in extravillous trophoblast invasion ... 12035976 - Piglet and placental traits at term in relation to the estrogen receptor genotype in gi... 426026 - Placental uptake and transfer of lipid in the postterm rabbit. 20420276 - Correlations of fetal-maternal outcomes and first trimester 3-d placental volume/3-d po... 19406396 - Conservative surgical management for diffuse uterine adenomyosis. 8595716 - Urine sulfatides and the diagnosis of metachromatic leukodystrophy. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Early human development Volume: 86 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-08-03 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
|
Languages: eng Pagination: 451-6 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of OBGYN, Meir Medical Center, Kfar Saba, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Female Fetal Growth Retardation / etiology, genetics* Humans Immunohistochemistry In Situ Hybridization, Fluorescence Placental Insufficiency / genetics* Pregnancy Telomere / ultrastructure* Trophoblasts / ultrastructure* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Susceptibility of rapidly growing mycobacteria isolated from cats and dogs, to ciprofloxacin, enrofl...
Next Document: Stability of neurocranial signs in the first two years of life in infants at risk.