| Telomere shortening in leukocyte subpopulations from baboons. | |
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MedLine Citation:
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PMID: 12554806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To address questions about telomere length regulation in nonhuman primates, we studied the telomere length in subpopulations of leukocytes from the peripheral blood of baboons aged 0.2-26.5 years. Telomere length in granulocytes, B cells, and subpopulations of T cells all decreased with age. Overall, telomere length kinetics were lineage- and cell subset-specific. T cells showed the most pronounced, overall decline in telomere length. Levels of telomerase in stimulated T cells from old animals were lower than in corresponding cells from young animals. Memory T cells with very short telomeres accumulated in old animals. In contrast, the average telomere length values in B cells remained relatively constant from middle age onward. Individual B cells showed highly variable telomere length, and B cells with very long telomeres were observed after the ages of 1-2 years. In general, cell type-specific telomere kinetics in baboons were remarkably similar to those observed in humans. |
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Authors:
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Gabriela M Baerlocher; Jennifer Mak; Alexander Röth; Karen S Rice; Peter M Lansdorp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 73 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-29 Completed Date: 2003-02-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 289-96 Citation Subset: IM |
Affiliation:
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Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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genetics Animals Female Leukocytes / metabolism* Male Papio T-Lymphocytes / enzymology Telomerase / metabolism Telomere* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI 29524/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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