Document Detail

Telomere recombination and alternative telomere lengthening mechanisms.
MedLine Citation:
PMID:  23276906     Owner:  NLM     Status:  MEDLINE    
Telomeres are nucleoprotein structures at the ends of linear chromosomes that protect them from being recognized as DNA double stranded breaks. Telomeres shorten with every cell division and in the absence of the checkpoint mechanisms critical telomere shortening leads to chromosome end fusions and genomic instability. Cancer cells achieve immortality by engaging in one of the two known mechanisms for telomere maintenance: elongation by telomerase or through recombination. Recombination based elongation of telomeres, also known as alternative lengthening of telomeres or ALT, is prevalent among cancers of mesenchymal origin. However, the conditions favoring ALT emergence are not known. Here we will discuss possible players in ALT mechanisms, including recruitment of telomeres to recombination centers, alterations of telomere associated proteins and modifications at the level of chromatin that could generate recombination permissive conditions at telomeres.
Irena Draskovic; Arturo Londono Vallejo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-20     Citation Subset:  IM    
Institut Curie, Centre de recherche, 75005 Paris, France.
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MeSH Terms
DNA Helicases / metabolism
DNA Methylation / physiology
Exodeoxyribonucleases / metabolism
Genomic Instability
Heterochromatin / metabolism
RecQ Helicases / metabolism
Recombination, Genetic
Telomerase / metabolism
Telomere / metabolism*
Telomere Homeostasis / physiology*
Telomere Shortening
Telomere-Binding Proteins / physiology
Reg. No./Substance:
0/Heterochromatin; 0/Telomere-Binding Proteins; 0/shelterin, human; EC; EC 3.1.-/Exodeoxyribonucleases; EC 3.6.1.-/Bloom syndrome protein; EC 3.6.1.-/DNA Helicases; EC 3.6.1.-/RecQ Helicases; EC 3.6.1.-/WRN protein, human; EC 3.6.1.-/regulator of telomere length protein, mouse

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