Document Detail


Telomere length variation in juvenile acute myocardial infarction.
MedLine Citation:
PMID:  23145125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (± 1 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.82 ± 0.16 p = 0.79 and t/s norm: 0.79 ± 0.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, β = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, β = -0.07). One hundred seventy-one cases (86%) ended the average follow up of 9 ± 5 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.
Authors:
Alessia Russo; Luigi Palumbo; Cristina Fornengo; Cornelia Di Gaetano; Fulvio Ricceri; Simonetta Guarrera; Rossana Critelli; Matteo Anselmino; Alberto Piazza; Fiorenzo Gaita; Serena Bergerone; Giuseppe Matullo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-07
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-06-25     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e49206     Citation Subset:  IM    
Affiliation:
Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Case-Control Studies
Cohort Studies
Coronary Artery Disease / complications,  genetics
Diabetes Complications / complications,  genetics
Genetic Markers
Genetic Variation*
Humans
Hypercholesterolemia / complications,  genetics
Hypertension / complications,  genetics
Middle Aged
Myocardial Infarction / complications,  genetics*
Prospective Studies
Telomere / metabolism*
Telomere Homeostasis*
Chemical
Reg. No./Substance:
0/Genetic Markers
Comments/Corrections

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