| Telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good treatment response and neutropenia severity. | |
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MedLine Citation:
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PMID: 17429195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the telomere length changes (DeltaTL) of peripheral blood mononuclear cells before and after repetitive standard-dose nonmyeloablative chemotherapy and the association of DeltaTL with treatment response and myelosuppression severity. TL was measured with Southern blot analysis in 32 solid-cancer patients without bone marrow metastasis. The mean TL before chemotherapy (t0 TL) and after the 2nd (t1 TL), 4th (t2 TL) and 6th cycle (t3 TL) was 8.49, 8.33, 8.08 and 8.10 kb, respectively. TL became significantly decreased after 4 (p = 0.005) and 6 (p = 0.026) cycles of chemotherapy. The mean value of DeltaTL before and after completion of chemotherapy (t0 TL - t3 TL) was 0.46 kb. DeltaTL has a significant correlation with good treatment response (r = 0.448, p = 0.005) and the frequency of severe neutropenia (r = 0.417, p < 0.05). Consequently, TL of peripheral blood mononuclear cells was decreased by the repetitive nonmyeloablative standard-dose chemotherapy in solid-cancer patients without bone marrow metastasis, and DeltaTL was associated with good treatment response and neutropenia severity. |
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Authors:
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So Young Yoon; Hwa Jung Sung; Kyong Hwa Park; In Keun Choi; Seok Jin Kim; Sang Cheul Oh; Jae Hong Seo; Chul Won Choi; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-11 |
Journal Detail:
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Title: Acta haematologica Volume: 118 ISSN: 1421-9662 ISO Abbreviation: Acta Haematol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-06-28 Completed Date: 2007-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 30-7 Citation Subset: IM |
Copyright Information:
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Copyright 2007 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, Konkuk University Hospital, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / administration & dosage*, adverse effects Cohort Studies Comorbidity Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Leukocytes, Mononuclear / drug effects, metabolism* Male Neoplasms / blood, drug therapy*, enzymology*, mortality Neutropenia / chemically induced, epidemiology* Probability Prospective Studies Risk Factors Sensitivity and Specificity Survival Analysis Telomerase / metabolism* Telomere / drug effects* Treatment Outcome Tumor Markers, Biological / blood |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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