| Telomere length is reset during early mammalian embryogenesis. | |
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MedLine Citation:
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PMID: 15148368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The enzyme telomerase is active in germ cells and early embryonic development and is crucial for the maintenance of telomere length. Whereas the different length of telomeres in germ cells and somatic cells is well documented, information on telomere length regulation during embryogenesis is lacking. In this study, we demonstrate a telomere elongation program at the transition from morula to blastocyst in mice and cattle that establishes a specific telomere length set point during embryogenesis. We show that this process restores telomeres in cloned embryos derived from fibroblasts, regardless of the telomere length of donor nuclei, and that telomere elongation at this stage of embryogenesis is telomerase-dependent because it is abrogated in telomerase-deficient mice. These data demonstrate that early mammalian embryos have a telomerase-dependent genetic program that elongates telomeres to a defined length, possibly required to ensure sufficient telomere reserves for species integrity. |
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Authors:
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Sonja Schaetzlein; Andrea Lucas-Hahn; Erika Lemme; Wilfried A Kues; Martina Dorsch; Michael P Manns; Heiner Niemann; K Lenhard Rudolph |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-05-17 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 101 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-26 Completed Date: 2004-07-09 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8034-8 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hepatology, and Endocrinology, and Institute for Animal Science, Hannover Medical School, 30625 Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blastocyst / metabolism Cattle Embryonic and Fetal Development / genetics* Gene Deletion In Situ Hybridization, Fluorescence Mammals / genetics Mice Mice, Knockout Morula / metabolism RNA / genetics Telomerase / deficiency, genetics Telomere / chemistry*, genetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/telomerase RNA; 63231-63-0/RNA; EC 2.7.7.49/Telomerase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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