| Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. | |
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MedLine Citation:
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PMID: 18155157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A relationship between telomeres and radiosensitivity has been established by several studies based on non-mammalian model systems, mouse models, and few human genetic diseases. However, the relationship has not been proven in human carcinoma cells, which have more clinical significance than these other models. The present study aims to determine whether telomere length is related to radiosensitivity in human carcinoma cells, and to examine the influence of tissue or genetic background. Two HEp-2 larynx squamous carcinoma cell lines, eight hepatocellular carcinoma cell lines, and five breast cancer cell lines were used. Telomere length was determined by terminal restriction fragment (TRF) Southern blot analysis and cell survival was measured by a colony-forming assay. Our results indicated that there was a significant negative correlation of telomere length and radiosensitivity in the same tissue-derived cell lines, with or without the same genetic background. Thus, telomere length may be used as a promising tool to predict the radiosensitivity of human carcinomas. |
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Authors:
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Ya-Hua Zhong; Zheng-Kai Liao; Fu-Xiang Zhou; Cong-Hua Xie; Chuang-Ying Xiao; Dong-Feng Pan; Zhi-Guo Luo; Shi-Quan Liu; Yun-Feng Zhou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-26 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 367 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 84-9 Citation Subset: IM |
Affiliation:
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Department of Chemo-Radiotherapy Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Southern Breast Neoplasms* / pathology, therapy Cell Line, Tumor / cytology, pathology, radiation effects Cell Survival / physiology, radiation effects Colony-Forming Units Assay Dose-Response Relationship, Radiation Gamma Rays* Humans Laryngeal Neoplasms* / pathology, therapy Liver Neoplasms* / pathology, therapy Telomere / physiology, radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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