| Telomere dynamics: the means to an end. | |
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MedLine Citation:
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PMID: 17635515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomeres are among the most important structures in eukaryotic cells. Creating the physical ends of linear chromosomes, they play a crucial role in maintaining genome stability, control of cell division, cell growth and senescence. In vertebrates, telomeres consist of G-rich repetitive DNA sequences (TTAGGG)n and specific proteins, creating a specialized structure called the telosome that through mutual interactions with many other factors in the cell give rise to dynamic regulation of chromosome maintenance. In this review, we survey the structural and mechanistic aspects of telomere length regulation and how these processes lead to alterations in normal and immortal cell growth. |
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Authors:
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M Matulić; M Sopta; I Rubelj |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell proliferation Volume: 40 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: England |
Other Details:
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Languages: eng Pagination: 462-74 Citation Subset: IM |
Affiliation:
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Ruder Bosković Institute, Department of Molecular Biology, Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle DNA Damage Telomere / chemistry, metabolism, physiology* Telomere-Binding Proteins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Telomere-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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