Document Detail

Telomerase-inhibitory effects of sugar-modified nucleotide analogs.
MedLine Citation:
PMID:  12903185     Owner:  NLM     Status:  MEDLINE    
Telomerase is an endogenous reverse transcriptase that uses its internal RNA moiety as a template for the synthesis of telomere repeats, thus maintaining telomere length. To study the susceptibility of telomerase to sugar-modified nucleotide analogs, inhibition by arabinofuranosylguanine 5'-triphosphate (araGTP), 3'-azido-2',3'-dideoxyguanosine 5'-triphosphate (AZdGTP), 2',3'-dideoxy-2'-fluoroarabino-furanosylguanine 5'-triphosphate (FaraGTP), and their thymine counterparts was investigated. Among these compounds, all dGTP analogs showed potent inhibitory activity against human telomerase. Conversely, dTTP analogs showed moderate or weak inhibition. Partially purified telomerase from cherry salmon testis utilized ddGTP and AZdGTP as substrates into the 3'-terminus of DNA.
Hiroshi Jinmei; Hazuki Takahashi; Rie Amano; Kaori Suzuki; Mineo Saneyoshi; Toyofumi Yamaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleic acids research. Supplement (2001)     Volume:  -     ISSN:  -     ISO Abbreviation:  Nucleic Acids Res. Suppl.     Publication Date:  2002  
Date Detail:
Created Date:  2003-08-07     Completed Date:  2003-09-08     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  101169367     Medline TA:  Nucleic Acids Res Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-2     Citation Subset:  IM    
Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.
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MeSH Terms
Carbohydrates / chemistry*
Nucleotides / chemistry*
Telomerase / antagonists & inhibitors*
Testis / enzymology
Reg. No./Substance:
0/Carbohydrates; 0/Nucleotides; EC

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