| Telomerase inhibition, telomere shortening, and decreased cell proliferation by cell permeable 2'-O-methoxyethyl oligonucleotides. | |
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MedLine Citation:
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PMID: 12459009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase is an attractive target for chemotherapy. Testing this hypothesis will require potent inhibitors with favorable pharmacokinetic properties. We report that 2'-methoxyethyl oligonucleotides complementary to the telomerase RNA component diffuse across cell membranes without the need for cationic carrier lipid, inhibit telomerase, and cause telomeres to shorten. The ability of antitelomerase oligomers to enter cells without the need to add lipid will simplify preclinical studies and may suggest advantages for clinical use. |
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Authors:
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Zhi Chen; Brett P Monia; David R Corey |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 45 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-02 Completed Date: 2003-01-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
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Languages: eng Pagination: 5423-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division
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drug effects Cell Membrane Permeability Enzyme Inhibitors / chemical synthesis*, chemistry, pharmacology Humans Oligonucleotides / chemical synthesis*, chemistry, pharmacology Structure-Activity Relationship Telomerase / antagonists & inhibitors* Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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CA70907/CA/NCI NIH HHS; CA85363/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Oligonucleotides; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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