| Telomerase in the ovary. | |
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MedLine Citation:
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PMID: 20562297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomerase, an enzyme complex that binds the chromosome ends (telomeres) and maintains telomere length and integrity, is present in germ cells, proliferative granulosa cells, germline stem cells, and neoplastic cells in the ovary, but it is absent in differentiated or aged cells. Activation of telomerase in the ovary underpins both benign and malignant cell proliferation in several compartments, including the germ cells, membrana granulosa, and the ovarian surface epithelium. The difference in telomerase operation between normal and abnormal cell proliferations may lie in the mechanisms of telomerase activation in a deregulated manner. Recent studies have implicated telomerase activity in ovarian cancer as well as oogenesis and fertility. Inhibition of telomerase and the shortening of telomeres are seen in occult ovarian insufficiency. Studies of how telomerase operates and regulates ovary development may provide insight into the development of both germ cells for ovarian reproductive function and neoplastic cells in ovarian cancer. The current review summarizes the roles of telomerase in the development of oocytes and proliferation of granulosa cells during folliculogenesis and in the process of tumorigenesis. It also describes the regulation of telomerase by estrogen in the ovary. |
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Authors:
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Jun-Ping Liu; He Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-18 |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 140 ISSN: 1741-7899 ISO Abbreviation: Reproduction Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: IM |
Affiliation:
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Molecular Signaling Laboratory, Department of Immunology, Monash University Central Clinical School, AMREP, Commercial Road, Melbourne, Victoria 3004, Australia. jun-ping.liu@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Proliferation Estrogens / physiology Female Gene Expression Regulation, Enzymologic Granulosa Cells / cytology, physiology Humans Oogenesis / physiology Ovarian Neoplasms / enzymology Ovary / enzymology* Telomerase / physiology* Telomere / physiology |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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