Document Detail


Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again.
MedLine Citation:
PMID:  11841477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomerase is a ribonucleoprotein complex that catalyses the addition of TTAGGG repeats onto telomeres, repetitive DNA structures found at the ends of linear chromosomes. The majority of human somatic tissues do not display telomerase activity and undergo telomeric shortening with consecutive divisions. This telomeric shortening results in replicative senescence in vitro and likely in vivo. Telomerase activity is present in the vast majority of tumors, preventing telomeric shortening and thereby enabling indefinite cell divisions. Telomerase activity is regulated throughout human development, undergoing silencing in almost all organ systems from embryogenesis onwards. However, regulated telomerase activity is seen in basal/stem cell compartments of highly regenerative tissues, such as those of the immune system, skin, and intestine. Avian species display telomerase repression and telomeric shortening similar to that seen in humans. However, rodents retain telomerase-competency throughout their lifespan and have not been shown to display division-dependent telomere shortening. The regulation of telomerase activity in plants is less well understood, although early indications suggest ubiquitous competency. The aim of this review is to present current data regarding developmental regulation of telomerase in humans, mice, chickens and flowering plants. Differentiation, quiescence and telomerase activity regulation will then be addressed in three human representative tissue systems; blood, skin, and intestine. We will also highlight similarities, differences and misconceptions in the developing field of telomere and telomerase biology.
Authors:
Nicholas R Forsyth; Woodring E Wright; Jerry W Shay
Related Documents :
21139567 - Mcl-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
21466787 - Cytochrome p4504f, a potential therapeutic target limiting neuroinflammation.
21182827 - Nf-kappab inhibition improves the sensitivity of human glioblastoma cells to 5-aminolev...
21376737 - Influence of low dose irradiation on differentiation, maturation and t-cell activation ...
25113747 - Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients wit...
24664247 - Multi-organ lesions in suckling mice infected with sars-associated mammalian reovirus l...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  69     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  188-97     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arabidopsis / enzymology,  genetics
Cell Differentiation*
Cell Division
Chickens
Epidermis / enzymology
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Hematopoietic Stem Cells / enzymology
Humans
Intestinal Mucosa / enzymology
Mice
Nuclear Transfer Techniques
Telomerase / genetics,  metabolism*
Telomere / genetics
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cloning humans? Current science, current views, and a perspective from Christianity.
Next Document:  Notch signaling is involved in the regulation of Id3 gene transcription during Xenopus embryogenesis...