Document Detail


Telomerase as a therapeutic target.
MedLine Citation:
PMID:  8922038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ribonucleoprotein telomerase is an enzyme that elongates telomeric DNA. In cells without detectable telomerase activity telomeres shorten with every cell generation and reaching critical length is a signal for cell death. Normal human somatic cells express undetectable, or low (bone marrow and peripheral leukocytes), telomerase activity. Reactivation of telomerase (immortalization) is probably necessary during development of a fully malignant cancer. Consequently, telomerase was proposed to be a therapeutic target for the cancer therapy. Potential results (including side-effects) of telomerase inhibition are being considered. After all, telomerase inhibition can be useful not only in the therapy, but also in cancer biology research, elucidating ageing and immortalization phenomena.
Authors:
L Huminiecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta biochimica Polonica     Volume:  43     ISSN:  0001-527X     ISO Abbreviation:  Acta Biochim. Pol.     Publication Date:  1996  
Date Detail:
Created Date:  1997-02-18     Completed Date:  1997-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  14520300R     Medline TA:  Acta Biochim Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Affiliation:
Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Aging
Cells, Cultured
Enzyme Activation
Humans
Models, Biological
Rodentia
Telomerase / antagonists & inhibitors,  metabolism*
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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