| Telomerase activity with concurrent loss of cell cycle regulation in feline post-traumatic ocular sarcomas. | |
| | |
MedLine Citation:
|
PMID: 16154137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Paraffin wax-embedded ocular globes of cats with post-traumatic ocular sarcomas were examined for the presence of TERT, the active subunit of telomerase. The latter is a ribonucleoprotein complex essential for immortalization and expressed by most malignant tumours, germ line cells, lens epithelial cells, and some stem cells. Due to the frequent loss of cell cycle control with the increased expression of telomerase activity, post-traumatic ocular sarcomas were also examined for loss of p16 expression and alterations in p53, the findings being related to mitotic score, tumour grade, and proliferating cell nuclear antigen. These sarcomas expressed telomerase at a high frequency (62.5%); in addition, the majority showed alterations in cell cycle control, as evaluated by lack of p16 immunolabelling (66.7%). Alterations in p53 were the sole mechanism by which cell cycle control was dysregulated in only two tumours expressing TERT (13%). These findings suggest that p16, and not p53, represents the primary mechanism by which post-traumatic ocular sarcomas that express telomerase activity escape cell cycle control. |
| | |
Authors:
|
R T Carter; C Giudice; R R Dubielzig; C M H Colitz |
Related Documents
:
|
8536797 - Methodologic considerations for the use of canine in vivo aged biotinylated erythrocyte... 12717417 - Delivering antisense telomerase rna by a hybrid adenovirus/ adeno-associated virus sign... 1248587 - Cell types originating from kidney explants of young and old mice. 9539717 - Telomere loss in cells treated with cisplatin. 20175747 - Rho gtpases: regulation of cell polarity and growth in yeasts. 20799797 - Alterations in the characteristic size distributions of subcellular scatterers at the o... |
Publication Detail:
|
Type: Journal Article Date: 2005-09-08 |
Journal Detail:
|
Title: Journal of comparative pathology Volume: 133 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 2005 Nov |
Date Detail:
|
Created Date: 2005-11-07 Completed Date: 2005-12-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: England |
Other Details:
|
Languages: eng Pagination: 235-45 Citation Subset: IM |
Affiliation:
|
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cat Diseases / enzymology*, genetics, pathology Cats Cell Cycle / genetics, physiology* DNA-Binding Proteins / genetics, metabolism* Eye / chemistry, enzymology, pathology Eye Neoplasms / enzymology, pathology, veterinary* Female Gene Expression Regulation, Neoplastic Genes, p16 Genes, p53 Male Mitosis Neoplasms, Post-Traumatic / enzymology, pathology, veterinary* Proliferating Cell Nuclear Antigen / genetics, metabolism Sarcoma / enzymology, pathology, veterinary* Telomerase / genetics, metabolism* Tumor Suppressor Protein p14ARF / genetics, metabolism Tumor Suppressor Protein p53 / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/DNA-Binding Proteins; 0/Proliferating Cell Nuclear Antigen; 0/Tumor Suppressor Protein p14ARF; 0/Tumor Suppressor Protein p53; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relaxation phenomena of polyethyleneimine molecules within saturated homogeneous and heterogeneous l...
Next Document: Gastroinvasive Helicobacter infection in an Ocelot (Leopardus pardalis).