Document Detail

Telomerase activity is not altered by regular strenuous exercise in skeletal muscle or by sarcoma in liver of rats.
MedLine Citation:
PMID:  11450989     Owner:  NLM     Status:  MEDLINE    
Telomerase is a specialized ribonucleoprotein enzyme complex which prevents the loss of the telomere. The activity of telomerase can be up- and down-regulated by various oxidative stresses but the effect of physical exercise is not known, whereas the modifying effect of cancer on telomerase activity is well documented. In the first study, we investigated the effect of mild and strenuous exercise training on telomerase activity, assessed by a PCR ELISA kit. No alteration in telomerase activity was detected. In the second investigation, solid sarcoma cells were transplanted to control, exercise trained or exercise trained and still exercising mice. On the 16th day after the transplantation, the size of tumors in the exercise trained group was 72% and in the exercising group 57% (P < 0.05) of that in the controls. Telomerase activity and 8-hydroxy-2'-deoxyguanosine levels in the liver were not significantly altered by exercise and/or sarcoma. We conclude that mild and strenuous exercise training does not significantly affect the activity of telomerase in the systems studied. Exercise training during sarcoma significantly retards the development of tumors and could possibly serve as a positive adjunct to treatment.
Z Radak; A W Taylor; M Sasvari; H Ohno; B Horkay; J Furesz; D Gaal; T Kanel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  6     ISSN:  1351-0002     ISO Abbreviation:  Redox Rep.     Publication Date:  2001  
Date Detail:
Created Date:  2001-07-13     Completed Date:  2002-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Laboratory of Exercise Physiology, School of Sport Sciences, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Crosses, Genetic
DNA Damage
Deoxyguanosine / analogs & derivatives*,  analysis
Liver / enzymology*
Liver Neoplasms, Experimental / chemistry,  enzymology*
Mice, Inbred C57BL
Mice, Inbred DBA
Muscle, Skeletal / enzymology*
Neoplasm Transplantation
Oxidative Stress
Physical Conditioning, Animal / physiology*
Physical Exertion / physiology*
Rats, Wistar
Sarcoma, Experimental / chemistry,  enzymology*
Stress, Physiological / enzymology*
Telomerase / metabolism*
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 961-07-9/Deoxyguanosine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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