Document Detail

Telomerase activity is maintained throughout the lifespan of long-lived birds.
MedLine Citation:
PMID:  17470387     Owner:  NLM     Status:  MEDLINE    
Telomerase is an enzyme capable of elongating telomeres, the caps at the ends of chromosomes associated with aging, lifespan and survival. We investigated tissue-level variation in telomerase across different ages in four bird species that vary widely in their life history. Telomerase activity in bone marrow may be associated with the rate of erythrocyte telomere shortening; birds with lower rates of telomere shortening and longer lifespans have higher bone marrow telomerase activity throughout life. Telomerase activity in all of the species appears to be tightly correlated with the proliferative potential of specific organs, and it is also highest in the hatchling age-class, when the proliferative demands of most organs are the highest. This study offers an alternative view to the commonly held hypothesis that telomerase activity is down-regulated in all post-mitotic somatic tissues in long-lived organisms as a tumor-protective mechanism. This highlights the need for more comparative analyses of telomerase, lifespan and the incidence of tumor formation.
Mark F Haussmann; David W Winkler; Charles E Huntington; Ian C T Nisbet; Carol M Vleck
Related Documents :
15141167 - Molecular analysis of telomere fusions in arabidopsis: multiple pathways for chromosome...
15256487 - Drosophila atm/telomere fusion is required for telomeric localization of hp1 and telome...
9402027 - Telomeres of the linear chromosomes of lyme disease spirochaetes: nucleotide sequence a...
9146697 - Telomeres, telomerase and chromosome stability.
17292877 - Gender effects on the incidence of aneuploidy in mammalian germ cells.
7920657 - Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome m...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-03-27
Journal Detail:
Title:  Experimental gerontology     Volume:  42     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  610-8     Citation Subset:  IM    
Department of Biology, Kenyon College, Gambier, OH 43022, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Marrow / growth & development,  physiology
Life Expectancy*
Organ Specificity
Ovary / growth & development
Songbirds / growth & development*,  physiology*
Telomerase / metabolism*
Testis / growth & development
Tissue Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impairments of heat shock protein expression and MAPK translocation in the central nervous system of...
Next Document:  Protective action of honokiol, administered orally, against oxidative stress in brain of mice challe...