Document Detail


Telomerase activity in oral lichen planus.
MedLine Citation:
PMID:  9736429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine the expression of telomerase in refractory oral lichen planus. Using a polymerase chain reaction-based telomerase activity assay, we investigated telomerase activity in 20 oral lichen planus specimens (erosive 9, atrophic 11). Telomerase activity was detected in 14 cases (erosive 7, atrophic 7). Furthermore, 13 cases of lichen planus with mild dysplasia proved telomerase-positive in eight specimens and six of seven cases devoid of dysplasia were also positive in the telomerase assay. The data indicate that, in general, telomerase activity might be frequently detectable in OLP. The data also suggest that telomerase activity might not be particularly associated with the premalignant phenotype in OLP.
Authors:
K Thongprasom; A Mutirangura; S Cheerat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  27     ISSN:  0904-2512     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-24     Completed Date:  1998-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  D; IM    
Affiliation:
Oral Medicine Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Female
Humans
Lichen Planus, Oral / enzymology*,  pathology
Male
Middle Aged
Mouth Mucosa / enzymology*,  pathology
Telomerase / metabolism*
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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